Disclaimer | In Crisis?
If you are in crisis or contemplating self-harm or suicide, please call 988 or visit 988Lifeline.org, which provides free and confidential emotional support to people in suicidal crisis or emotional distress 24/7 in the United States. An extensive list of International suicide prevention hotlines can be found there. Remember: You are needed, you deserve to be here, and you are not alone. Reach out, and do not give up.
Having a Challenging Trip?
If you are experiencing a difficult psychedelic event, or still need help processing one, call or text 62-FIRESIDE. The Fireside Project offers free emotional support during or after a psychedelic experience. You can also download their app. Their services are completely confidential, and their staff is rigorously trained, compassionate, and knowledgeable regarding psychedelics. You can also contact SAMHSA’s National Helpline at (800) 622-HELP (4357). Their confidential helpline is available 24/7 in English and Spanish for individuals and family members experiencing emotional distress or crisis.
Additional support resources can be found in the Zendo Project directory. The Zendo Project was founded in partnership with the Multidisciplinary Association for Psychedelic Studies. Their extensive list of harm reduction resources, emotional support services, and peer support hotlines offer a vast array of tools to help you move through a challenging experience and come out the other side feeling empowered and secure.
Having a Medical Emergency?
If you or a loved one are experiencing a medical emergency and require immediate attention, please dial 911 (USA) immediately.
Are You a Veteran Having a Medical Emergency?
If you are a veteran experiencing a difficult trip or crisis, please contact (800) 273-8255 and Press 1. This will connect you to the Veteran Crisis Line. Their hotline is staffed by experienced personnel, many of whom are also veterans. A trained responder will answer your call 24/7 to help you through a crisis, anxiety, or thoughts of self-harm.
Emotional and Crisis Support for the LGBTQIA+ Community.
Members of the LGBTQIA+ community may face unique and difficult situations during a challenging psychedelic experience. If you need emotional or crisis support, dial (888) 688-5428 or visit LGBThotline.org. Their hotline is designed for people of all ages and staffed by a dedicated team of highly trained volunteers from all parts of the LGBT+ community. They also offer a dedicated line for LGBT+ seniors that you can reach at (888) 234-7243.
Be Wary of Fentanyl-Contaminated Drugs.
The United States is experiencing a synthetic opioid epidemic that has claimed thousands of lives due to street drugs being adulterated with other drugs, such as fentanyl. Fentanyl is an incredibly powerful and deadly narcotic, with doses as low as two milligrams (a dose so small it could fit on the tip of a pencil) being potentially deadly. While it is never recommended to consume any illicit substances, it is critical that you or the people you know test any drugs you may ingest for fentanyl. Several non-profit harm reduction organizations, such as DanceSafe, offer fentanyl testing strips and at-home drug testing kits.
The information we provide is not intended to be a substitute for professional medical advice, diagnosis, or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider. Some individuals with preexisting mental health conditions should not use psychedelics. Always consult with a trained medical professional about your specific healthcare needs.
Are Psychedelics Legal?
Most classical and non-classical psychedelic drugs are prohibited in the United States under the Controlled Substances Act of 1970. This family of chemical compounds are considered Schedule I drugs, the most tightly controlled and generally illegal class. This includes psilocybin (aka Magic Mushrooms), Methylenedioxymethamphetamine (MDMA), Lysergic acid diethylamide (LSD), N,N-Dimethyltryptamine (DMT), Ayahuasca, Ibogaine, Peyote, 2C-B, Cannabis, and others. Ketamine is also controlled under the same act and listed as a Schedule III drug. Due to the illegal or controlled nature of these drugs, it is not advised that you attempt to purchase, source, or otherwise possess any Scheduled substances, as you may be at risk of civil and criminal penalties.
The information provided on this website is intended for informational and harm reduction purposes only and does not constitute medical or legal advice. Nor is this information, or any journalistic stories, anecdotes, visual or artistic material intended as a replacement or supplement for medical or legal advice. It is important to understand that using any psychedelic compounds from the streets has significant risks and is unlikely to produce the promising results emerging in some clinical trials which involve particular dosing and purity, along with specific, carefully crafted psychotherapy in a safe, controlled environment. Various psychedelics purchased illegally often are adulterated with other, possibly harmful substances, making it difficult and not advisable to self-medicate for PTSD, anxiety, depression, or for the treatment of other mental health issues.
In this week’s Psychedelic News Roundup, a novel crusade is underway in the heart of Ukraine amid the relentless strife of war. Medical experts, recognizing the profound mental toll of sustained conflict, are advocating for an unconventional solution: the legalization of therapeutic psychedelics. Other psychedelic news includes discoveries about the interaction of psychedelics and the Default Mode Network (DMN), and the launch of Clear Mind Medicine’s new alcohol use disorder research partnership with two Ivy League universities.
Psychedelic Therapeutic Frontiers in Wartime Ukraine
As covered by DW News, amidst the mental health crisis exacerbated by the war with Russia, Ukrainian experts are advocating for the legalization of psychedelics such as LSD, psilocybin from magic mushrooms, and MDMA for therapeutic use, particularly to treat PTSD in soldiers. Ksenia Voznitsyna from the Ukrainian Health Ministry is leading the campaign, pushing for legislative changes to allow psychedelic-assisted therapy, which she believes can expedite the healing process in complex cases unresponsive to traditional treatments.
Psychedelic-assisted therapy involves conversational psychotherapy while patients are under the influence of substances like psilocybin or MDMA, conducted in clinical settings under professional supervision. This method requires up to eight hours per session and is gaining traction in Ukraine despite traditionalist opposition. In the U.S., this approach is supported by veterans’ organizations and the Department of Veterans Affairs, with MDMA therapy possibly being authorized by 2024 following encouraging phase-three study results.
Research on psychedelics is active in Europe, with the European Medicines Agency conducting multiple studies on MDMA and psilocybin. In Germany, a trial on psilocybin for treatment-resistant depression is showing promising results for early-stage intervention. However, experts like psychiatrist Gerhard Gründer remain skeptical, especially regarding the ethical implications of such therapies in a war zone, cautioning against the risks of retraumatization and the complexities of using psychedelics in clinical trials for PTSD.(1)
Rewiring the Mind: Psychedelics’ Influence on Brain Networks
A story, originally run by Psychedelic Spotlight, highlights new information that is contrary to previous research that suggested psychedelics suppress activity in the Default Mode Network (DMN), a hub associated with introspection and self-awareness, a novel study indicates these substances may actually stimulate parts of the DMN. This new understanding extends to the Theory of Mind (ToM) Network, which is crucial for empathy and perspective-taking. The overlap of these networks under the influence of psychedelics could explain the profound sense of connectedness and altered self-perception reported during psychedelic experiences.
A meta-analysis of 88 studies encompassing over 2,000 participants revealed that specific brain regions, notably within the cingulate cortex, are implicated in both the DMN and ToM functions. These regions are active during rest (associated with the DMN) and social cognition tasks, suggesting that the DMN’s role in social cognition may be more generalized than previously thought. This finding challenges the hypothesis that the DMN and ToM are distinct networks, hinting at a more integrated approach to understanding social cognition.
These insights offer exciting implications for the therapeutic potential of psychedelics, particularly in conditions characterized by social cognition deficits like autism and neurodegenerative diseases. By affecting the brain regions that underlie our social interactions and self-reflection, psychedelics might enhance the ability to empathize and connect with others, offering a valuable tool in the treatment of these disorders. This study underscores the complexity of the brain’s social circuits and the potential role of psychedelics in navigating and potentially healing these intricate pathways.(2)
A New Horizon for Veterans’ Mental Health
The Military Times‘ recent article discusses how Juliana Mercer, a 15-year Marine Corps veteran, became an advocate for MDMA and psychedelic-assisted therapies to address mental health issues in veterans after her own healing experience with psilocybin in Costa Rica. MDMA has been recognized as a “breakthrough therapy” by the FDA for PTSD treatment, with promising results from clinical trials conducted by the Multidisciplinary Association of Psychedelic Studies (MAPS). These trials demonstrated significant improvements in PTSD symptoms, with a substantial portion of participants no longer meeting the diagnostic criteria for PTSD after treatment.
The success of psychedelic therapies comes as a mental health crisis affects veteran communities, with high rates of PTSD and suicide. Despite this, current trials lack federal support and funding. Advocates like Mercer urge lawmakers to provide financial backing, especially as MDMA therapy nears FDA approval, expected by next year, with psilocybin treatments following a few years later. Lawmakers have responded by proposing amendments to the Veterans Affairs appropriations bill to set up pilot programs for breakthrough therapies, emphasizing the urgency to support veterans through these innovative treatments.
The proposed legislative amendment aims to fast-track research and access to psychedelic therapies within the VA, with bipartisan support emphasizing the potential of these treatments to revolutionize mental health care for veterans. The push comes amidst legislative delays and a pressing deadline that threatens to stall funding. Despite these challenges, advocates like Mercer view MDMA therapies as a beacon of hope for veterans who have PTSD, potentially transforming mental health care nationwide.(3)
Unlocking the Mind: The Potential of Psychedelic-Assisted Psychotherapy
As detailed by the High Times, recent studies have cast light on the transformative power of psychedelic-assisted psychotherapy, especially for those with terminal illnesses. Psilocybin, a psychoactive compound found in magic mushrooms, when combined with psychotherapy, has been shown to drastically improve patients’ mood and acceptance of their condition in just a single session. The profound psychological changes and the potential for lasting positive effects offer a beacon of hope for those grappling with end-of-life distress.
Advancements in neuroscience have shed light on the mechanics behind these therapeutic successes. Research from Yale indicates that psilocybin can stimulate the rapid formation of neural connections in the brain’s frontal cortex, promoting cognitive and emotional growth. This development of new neuronal pathways, or arborization, is believed to be a critical factor in achieving the significant improvements observed in patients undergoing psychedelic-assisted psychotherapy.
The article also notes the natural occurrence of DMT, a psychedelic molecule, in the human brain, positing its potential role in mental adaptation processes. However, it cautions that while the science of psychedelics promises revolutionary treatments for mental health conditions, the unpredictability of individual experiences, including the possibility of adverse reactions, underscores the need for controlled, therapeutic settings and further research.(4)
Clearmind Medicine Advances Psychedelic Trials for AUD with Top Universities
Announced via Yahoo Finance, Clearmind Medicine Inc. has partnered with Johns Hopkins University School of Medicine and Yale University for a landmark clinical trial targeting Alcohol Use Disorder (AUD). Their pioneering treatment, CMND-100, is based on MEAI, a proprietary compound intended to curb the severe impacts of AUD, which range from health detriments to social and occupational disruptions.
The clinical trial, titled CM-CMND-001, is set to be a rigorous, multi-center study spanning multiple nations. It aims to test the safety, tolerability, and pharmacokinetics of CMND-100 through oral capsules given daily over ten days. Participants will be evaluated for changes in alcohol and cigarette cravings, as well as alterations in drinking behavior and signs of depression.
This Phase I/IIa trial is designed to discover the maximum tolerable dose and to understand the pharmacodynamics of CMND-100 in both healthy volunteers and individuals suffering from moderate-to-severe AUD. CMND-100 is a novel psychoactive molecule reportedly able to reduce the desire to consume alcoholic beverages while exerting a euphoric alcohol-like experience. A secondary goal is to assess the potential efficacy of the treatment in reducing alcohol dependence and cravings, with an exploratory focus on its impact on depressive symptoms.(5)
From war-ravaged Ukraine to the halls of Ivy League institutions, psychedelic medicine is making headlines and alleviating suffering. New discoveries regarding the interaction of psychedelics with the brain and continued calls for legislative reform in Washington showcase a world ready for psychedelic medicine to finally become accessible for all. However, further research is needed to ensure that psychedelic medicine is not only safe but also highly effective, especially for those who need it most.
This material is not intended as a replacement or substitute for any legal or medical advice. Always consult a medical professional about your health needs. Psychedelics are widely illegal in the United States, and readers should always be informed about local, state, and federal regulations regarding psychedelics or other drugs.
- Should ecstasy and mushrooms be legalized to treat PTSD? – DW – 11/06/2023. (n.d.). Dw.com. Retrieved November 9, 2023, from https://www.dw.com/en/should-ecstasy-mushrooms-be-legalized-to-treat-ptsd/a-67313910
- Holyanova, M. (2023, July 31). New Study Provides Insights into Psychedelics’ Impact on the DMN, ToM, and Social Cognition. Psychedelic Spotlight. https://psychedelicspotlight.com/new-study-provides-insights-into-psychedelics-impact-on-the-dmn-tom-and-social-cognition/
- Perez, Z. (2023, November 8). Psychedelics may soon be available — sort of — to treat vets with PTSD. Military Times. https://www.militarytimes.com/news/your-military/2023/11/08/psychedelics-may-soon-be-available-sort-of-to-treat-vets-with-ptsd/
- Thomas, S. S. (2023, November 9). Research Shows Science Behind Psychedelics, Psychotherapy’s Ability To Cause Quick Brain Changes. High Times. https://hightimes.com/psychedelics/research-shows-science-behind-psychedelics-psychotherapys-ability-to-cause-quick-brain-changes/
- Clearmind Medicine Inc. (2023, November 9). Clearmind Medicine to Pioneer Psychedelic Clinical Trials for Alcohol Use Disorder with Ivy League Universities. Yahoo Finance. https://finance.yahoo.com/news/clearmind-medicine-pioneer-psychedelic-clinical-142000453.html?guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&guce_referrer_sig=AQAAAKIuhY39DXOJzG9yC35498xnUMwDkXB-QE39xfhn8vMfKOdmVc9UqL1DXXS5rDagK9wXhlo1Ub4x7Dx5oNI_yi0IrQFeAbCfEuAKeTUKvKW-fHqr5KzCf5W2TVmOH_aAefjSHlUUF24SwvtT7SYeim6MGyAN4IAYCsCdpW9VNqaU&guccounter=2